Sproles has not played since the season opener.
Philadelphia also has defensive end Michael Bennett (foot) active.
Washington’s inactives are receiver Trey Quinn (ankle), cornerback Quinton Dunbar (shin), running back Sajame Perine, running back Byron Marshall, offensive tackle Austin Howard and defensive tackle Matt Ioanniois (shin).
Running back Adrian Peterson (shoulder) will play as will tight end Jordan Reed (back) and receiver Jamison Crowder (ankle). All three were listed as questionable. Running back Chris Thompson makes his return after missing six of the past seven games with a rib injury.